Bone

Hypertrophic Osteoarthropathy

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Hypertrophic Osteoarthropathy, Osteoarthropathy, Acropachy

  • See Also
  1. Clubbing
  • Definition
  1. Excess skin and bone proliferation at distal extremity
  • Pathophysiology
  1. Large Platelets accumulate in distal extremities
  2. Fibroblast growth factors released
  3. Results in edema and excess Collagen deposition
  4. Increased bone formation distally also occurs
  • Causes
  1. See Hypertrophic Osteoarthropathy Causes
  • Symptoms
  1. Often asymptomatic
  2. Deep bone pain at distal extremities (usually legs)
  • Signs
  1. Digital Clubbing
  2. Bone thickening of wrists and ankles
  • References
  1. Klippel (1997) Primer Rheumatic Diseases, p. 370-1