Lab

Serum Cystatin C

search

Serum Cystatin C, Cystatin C, Cystatin 3, Gamma Trace, Post-gamma-globulin, Neuroendocrine Basic Polypeptide

  • See Also
  1. Creatinine Clearance
  2. Chronic Kidney Disease
  • Background
  1. Protein (120 Amino Acid) found in all human cells with a nucleus, as well as nearly all body fluids and tissues
  • Indications
  1. Alternative to Serum Creatinine as a measure of GFR
    1. Consider when estimated GFR is decreased, with suspected False Positive test
    2. Abnormal GFR measurement with no known structural Kidney disease, CKD risk factors or albuminuria
  • Contraindications (inaccurate Serum Cystatin-C)
  1. Acute Kidney Injury
  2. Inflammatory states
  3. Thyroid dysfunction
  • Disadvantages
  1. May not be available at all facilities
  • Resources
  1. National Kidney Foundation GFR Calculator
    1. https://www.kidney.org/professionals/kdoqi/gfr_calculator
  2. Wikipedia
    1. https://en.wikipedia.org/wiki/Cystatin_C
  • References
  1. Stevens (2008) Am J Kidney Dis 51(3): 395-406 [PubMed]