Serum Cystatin C


Serum Cystatin C, Cystatin C, Cystatin 3, Gamma Trace, Post-gamma-globulin, Neuroendocrine Basic Polypeptide

  • Background
  1. Protein (120 Amino Acid) found in all human cells with a nucleus, as well as nearly all body fluids and tissues
  • Indications
  1. Alternative to Serum Creatinine as a measure of GFR
    1. Consider when estimated GFR is decreased, with suspected False Positive test
    2. Abnormal GFR measurement with no known structural Kidney disease, CKD risk factors or albuminuria
  • Contraindications (inaccurate Serum Cystatin-C)
  1. Acute Kidney Injury
  2. Inflammatory states
  3. Thyroid dysfunction
  • Disadvantages
  1. May not be available at all facilities