Lab

Serum Cystatin C

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Serum Cystatin C, Cystatin C, Cystatin 3, Gamma Trace, Post-gamma-globulin, Neuroendocrine Basic Polypeptide

  • See Also
  1. Creatinine Clearance
  2. Chronic Kidney Disease
  • Background
  1. Protein (120 Amino Acid) found in all human cells with a nucleus, as well as nearly all body fluids and tissues
  2. Contrast with Creatinine, of which most originates in Muscle
  • Indications
  1. Alternative to Serum Creatinine as a measure of GFR
    1. Consider when estimated GFR is decreased, with suspected False Positive test
    2. Abnormal GFR measurement with no known structural Kidney disease, CKD risk factors or albuminuria
  1. Acute Kidney Injury
  2. Inflammatory states
  3. Thyroid dysfunction
  4. Congestive Heart Failure
  5. Cirrhosis
  6. Cancer
  7. Obesity (Body Mass Index >40 kg/m2)
  8. High dose Corticosteroid use
  9. High catabolic states (Tuberculosis, AIDS)
  • Disadvantages
  1. May not be available at all facilities
  • Resources
  1. National Kidney Foundation GFR Calculator
    1. https://www.kidney.org/professionals/kdoqi/gfr_calculator
  2. Wikipedia
    1. https://en.wikipedia.org/wiki/Cystatin_C
  • References
  1. Stevens (2008) Am J Kidney Dis 51(3): 395-406 [PubMed]