Pharm

Modafinil

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Modafinil, Provigil

  • Indications
  1. Narcolepsy
  2. Non-FDA approved use
    1. Attention Deficit Hyperactivity Disorder
    2. Fatigue in Multiple Sclerosis
    3. Excessive Sleepiness in Myotonic Dystrophy
  • Contraindications (relative)
  1. Coronary Artery Disease
  2. Hypertension
  3. Other cardiovascular disease
  • Mechanism
  1. Stimulant
  • Dosing
  • Adults
  1. ADHD: 100-300 mg PO qd (Not FDA approved)
  2. Narcolepsy: 200 mg qAM
  • Dosing
  • Children Age >5 years
  1. ADHD: 50-100 mg PO qd (Not FDA approved)
  1. May be slightly less effective then agents above
  2. Less addictive potential then agents above
  3. (1999) Med Lett Drugs Ther 41(1049):30-2 [PubMed]
  1. Only small studies to show effectiveness and safety
  2. References
    1. Rugino (2001) J Am Acad Child Adolesc Psychiatry 40 [PubMed]
    2. Taylor (2000) J Child Adolesc Psychopharmacol 10:311 [PubMed]
  • Adverse Effects
  1. Headache
  2. Nervousness
  3. Dizziness
  4. Depressed mood
  5. Anxiety
  6. Cataplexy
  7. Insomnia
  8. Diarrhea
  9. Nausea
  10. Xerostomia
  11. Anorexia
  12. Paresthesias
  13. Pharyngitis or Rhinitis
  • References
  1. (2003) Lexi-Comp Drug Database for Pocket PC (7/9/03)