Analgesic

Flurbiprofen

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Flurbiprofen, Ansaid

  • See Also
  1. NSAID
  • Indications
  1. See NSAID
  2. FDA approved indications
    1. Rheumatoid Arthritis
    2. Osteoarthritis
  3. Off label use
    1. Ankylosing Spondylitis
    2. Primary Dysmenorrhea
    3. Acute Gout
    4. Acute pain
    5. Juvenile Rheumatoid Arthritis
  • Contraindications
  1. See NSAID
  • Mechanism
  1. See NSAID
  2. NSAID in the propionic acid class
    1. Other NSAIDS in propionic acid class include Ibuprofen and Naproxen
  • Medications
  1. Flurbiprofen tablets: 50 mg, 100 mg
  • Dosing
  1. Adults
    1. Arthritis (OA/RA): 200 to 300 mg/day divided twice to four times daily (max single dose: 100 mg)
    2. Primary Dysmenorrhea: 50 mg orally daily
    3. Mild to moderate pain: 50 mg orally every 6 hours
  2. Children (off label, not FDA approved)
    1. Juvenile Rheumatoid Arthritis 4 mg/kg/day divided two to four times daily
  • Adverse Effects
  1. See NSAID
  • Safety
  1. See NSAID
  2. Considered safe in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)
  • Resources
  1. Flurbiprofen (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4e5c06f1-f279-4f2f-b10d-0f70005a27e6
  • References
  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia