Analgesic

Celecoxib

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Celecoxib, Celebrex

  • Class
  1. NSAID: COX2 Inhibitor
  2. Similar to Rofecoxib (Vioxx)
  3. Diaryl-substituted pyrazole
  • Advantages
  1. Less gastrointestinal adverse effects than other NSAIDs
    1. See NSAID Gastrointestinal Adverse Effects
  • Metabolism
  1. Oral Bioavailability: 22 to 40%
  2. Half Life: 11 hours
  3. Liver metabolism by Cytochrome P450: CYP2C9
    1. Levels raised with Accolate, Diflucan, and Lescol
  4. Inhibits Cytochrome P450: CYP2D6
    1. Increases levels of Beta Blockers and psychotropics
  1. Consider alternative agent: Rofecoxib (Vioxx)
  • Dosing
  1. Osteoarthritis: 200 mg PO qd (or 100 mg po bid)
  2. Rheumatoid Arthritis: 200 mg PO qd to bid
  3. Familial Adenoma Polyposis: 400 mg PO bid
  • Adverse Effects
  1. Celebrex appears safer than Ibuprofen in terms of Cardiovascular Risk
    1. Ruschitzka (2017) Eur Heart J +PMID:29020251 [PubMed]
  2. Abdominal Pain
  3. Diarrhea
  4. Dyspepsia
  5. Peptic Ulcer Disease risk (see COX2 Inhibitor)
  6. Does not increase Bleeding Time
  • References
  1. Michalets (1998) Pharmacotherapy 18:84 [PubMed]
  2. (1999) Med Lett Drugs Ther 41(1045): 11-14 [PubMed]