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Streptomycin

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Streptomycin

  • Indications
  1. Multi-drug Tuberculosis Treatment regimen
  • Mechanism
  1. Bactericidal antibiotic via Protein synthesis inhibition
    1. Binds 30s/50s ribosome site
  2. Does not penetrate CSF, and poorly penetrates infected cells
    1. Only 10% of drug penetrates Tb infected cells
  • Dosing
  1. Adult: 1 gram (15 mg/kg) IM daily
  2. Pediatric: 20 to 40 mg/kg/day
  • Pharmacokinetics
  1. Renal excretion
  • Adverse Effects
  1. Cranial Nerve 8 and Vestibular toxicity
    1. Vertigo
    2. Decreased Hearing acuity or Deafness
  2. Renal damage
  • Resources
  1. Streptomycin Powder for Injection Solution (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=abd1f64e-4283-4370-aae8-3666316aa36e
  • References
  1. (2012) Med Lett Drugs Ther 10(116): 29-36