Pharm

Salmeterol

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Salmeterol, Serevent, Advair, AirDuo Respiclick, Wixela Inhub

  • See Also
  1. Long-Acting Beta Agonist
  2. Formoterol
  3. Short-acting Beta Agonist
  4. Beta Agonist
  5. Single Maintenance and Reliever Therapy
  6. Moderate Persistent Asthma
  7. Severe Persistent Asthma
  8. COPD Management
  • Indications
  1. Moderate Persistent Asthma
  2. Severe Persistent Asthma
  3. Chronic Obstructive Pulmonary Disease
  4. Exercise Induced Asthma
  • Precautions
  1. See Long-Acting Beta Agonist
  2. Use in combination with CorticosteroidInhaler in Asthma
  3. Unlike Formoterol, cannot be used for Single Maintenance and Reliever Therapy
    1. Use only maintenance doses listed below (do NOT use as rescue medication)
  1. Salmeterol (Serevent) Dry Powder Diskus (50 ug/inhale)
    1. Asthma, COPD (age >=4 years)
      1. One inhalation every 12 hours
    2. Exercise Induced Asthma
      1. One inhalation 30 minutes before Exercise
  2. Serevent Inhalation aerosol MDI (21 ug/puff)
    1. Asthma, COPD
      1. Adults: 2 puffs every 12 hours
      2. Child: 1-2 puffs every 12 hours
    2. Exercise Induced Asthma
      1. Inhale 1-2 puffs at 30 minutes before Exercise
  1. Advair Diskus (Fluticasone/Salmeterol: 100/50, 250/50, 500/50)
    1. One puff twice daily
  2. Wixela Inhub (Fluticasone/Salmeterol)
    1. One puff twice daily
  3. AirDuo Respiclick (Fluticasone/Salmeterol: 55/14, 113/14, 232/14)
    1. Dose: One puff twice daily
  • Safety
  1. Pregnancy Category C
  2. Unknown safety in Lactation
  • Pharmacokinetics
  1. Onset 20 minutes
  2. Duration 12 hours
  • Drug Interactions
  1. Strong CYP3A4 Inhibitors (e.g. Ketoconazole)
    1. Increased Salmeterol levels
    2. Risk of QTc Prolongation
  • Resources
  1. Salmeterol (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=12d9728e-6b5c-4aee-bfb0-745e542ed2e4
  2. Salmeterol and Fluticasone
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=43a27267-2f2b-410d-9c30-9cb95f35d9a1
  • References
  1. (2022) Comparison of Asthma Medications, Presc Lett, #381217
  2. (2022) Inhaled Medications for COPD, Presc Lett, #381116
  3. (2020) Drugs for COPD, Med Lett Drug Ther 62: 137-44
  4. (2020) Drugs for Asthma, Med Lett Drug Ther 62: 193-200
  5. (2013) Presc Lett, 20(8): 43
  6. (2017) Presc Lett 24(7)
  7. (2001) Med Clin North Am 43(1104):39-40 [PubMed]
  8. Wilson (2001) Chest 119:2021-6 [PubMed]