Pharm

Dapsone

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Dapsone

  • Indication
  1. Second line Tuberculosis management agent
  2. Second line agent in Pneumocystis carinii Pneumonia
  3. First line in certain autoimmune Bullous Conditions
    1. Dermatitis Herpetiformis
    2. Linear IgA Dermatosis
    3. Chronic Bullous Disease of Childhood
  • Dose
  1. Dapsone 100 mg per day
  • Adverse Effects
  1. Hemoglobin decreased (1-2 grams)
  2. Reticulocytes increased (2-12%)
  3. Hemolysis in G6PD Deficiency
  4. Methemoglobinemia
  5. Peripheral Neuropathy (rare)
  6. Nausea or Vomiting
  7. Proteinuria or Albuminuria
  8. Nephrotic Syndrome
  9. Erythema Nodosum leprosum in Leprosy treatment (50%)
  • Contraindications
  1. G6PD Deficiency
  • Monitoring
  1. Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD)
    1. Screen for before starting Dapsone
  2. Complete Blood Count
    1. Obtain baseline and monthly while on Dapsone