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Respiratory Medications in Pregnancy

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Respiratory Medications in Pregnancy

  • See Also
  1. Asthma in Pregnancy
  2. Medications in Pregnancy
  • Background
  1. Pregnancy Categories will be replaced on medication bottles with specific warnings and precautions by 2020 in U.S.
    1. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm425317.htm
    2. Although FDA Pregnancy Categories are no longer FDA designated, they are included here
      1. As of 2018, succinct guidance (to replace ABCDX) on specific drugs in pregnancy is lacking
  • Class B
  • No risk in controlled animal studies
  1. Cromolyn Sodium (Intal)
  2. Ipratropium Bromide (Atrovent)
  3. Terbutaline (Brethine, Brethaire)
  4. Montelukast (Singulair) - not in Briggs (1998)
  5. Nedocromil (Tilade) - not in Briggs (1998)
  6. Zafirlukast (Accolate) - not in Briggs (1998)
  • Class C
  • Small risk in controlled animal studies
  1. Albuterol (Proventil, Ventolin)
  2. Beclomethasone (Vanceril, Beclovent)
    1. Most used Inhaled Corticosteroid in pregnancy
  3. Budesonide (Pulmicort) - not in Briggs (1998)
  4. Flunisolide (Aerobid) - not in Briggs (1998)
  5. Fluticasone (Flovent) - not in Briggs (1998)
  6. Inhaled Triamcinolone (Azmacort)
  7. Metaproterenol (Alupent)
  8. Pirbuterol (Maxair) - not in Briggs (1998)
  9. Salmeterol (Serevent) - not in Briggs (1998)
  10. Theophylline
  11. Zileuton (Zyflo) - not in Briggs (1998)
  • References
  1. Briggs (1998) Drugs in Pregnancy and Lactation, 5th ed
  2. Larimore (2000) Prim Care 27(1):35-53 [PubMed]