Pharm

Zileuton

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Zileuton, Zyflo

  • See Also
  1. Leukotriene Receptor Antagonist
  2. Montelukast
  3. Zafirlukast
  • Indications
  1. Severe Persistent Asthma
    1. Adjunct only
    2. Other Leukotriene Modifiers are preferred
  • Dosing
  1. Approved only in age >=12 years and only as adjunct in Severe Asthma
  2. Dose: 1200 mg orally two times daily
  • Mechanism
  1. Attenuates bronchoconstriction and inflammation
  2. Leukotriene Synthesis Inhibitor (inhibits 5-lipoxygenase)
    1. Contrast with Leukotriene Receptor Antagonists (Zafirlukast or Accolate, Montelukast or Singulair)
  • Adverse Effects
  1. See Leukotriene Receptor Antagonist
  2. More adverse effects than other Leukotriene Modifiers (e.g. Montelukast, Zafirlukast)
  3. Dyspepsia
  4. Nausea
  5. Hepatotoxicity (5% of patients)
    1. Monitor liver enzymes every 3 months
  • Efficacy
  1. See See Leukotriene Receptor Antagonist
  • Safety
  1. Pregnancy Category C
  2. Unknown safety in Lactation
  • Drug Interactions
  1. Zileuton increases other drug levels, potentiating their action
    1. Warfarin
    2. Theophylline
    3. Propranolol
  • Resources
  1. Zileuton (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d3d8cd1-e1a5-4a2e-a09d-9420b0168922
  • References
  1. (2020) Drugs for Asthma, Med Lett Drug Ther 62: 193-200
  2. (1996) Med Lett Drugs Ther 38:111-2 [PubMed]
  3. (2000) Med Lett Drugs Ther 42:22-3 [PubMed]
  4. Scow (2007) Am Fam Physician 75:65-70 [PubMed]
  5. Wilson (2001) Chest 119:2021-6 [PubMed]