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Quinupristin-Dalfopristin

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Quinupristin-Dalfopristin, Synercid, Streptogramin

  • See Also
  1. Anti-Ribosomal Antibiotic
  1. Vancomycin-resistant Enterococcus faecium
    1. Does not cover Enterococcus faecalis
  2. Methicillin susceptible Staphylococcus Aureus
  3. Methicillin susceptible Streptococcus Pyogenes
  • Mechanism
  1. Antibiotic Resistance is rare for its limited indications
  2. Anti-Ribosomal Antibiotic
    1. Binds the Bacterial 50S Ribosomal subunit
  • Pharmacokinetics
  1. Hepatic Clearance predominates
  2. Half-Life: 1-3 hours (9-10 hours of affect)
  • Adverse Effects
  1. Background
    1. Adverse effects are common and limit use (other medication options are preferred when available)
  2. Arthralgias or myalgias (40%)
  3. Infusion site pain (40%)
  4. Nausea, Diarrhea or Vomiting
  5. Hyperbilirubinemia
  6. Rash or Pruritus
  7. Headache
  1. Raises serum drug levels of substrates in 3A4 system
  2. Follow Cyclosporine levels when using concurrently
  • Dosing
  1. Enterococcus faecium: 7.5 mg/kg IV q8 hours
  2. Severe Skin Infections: 7.5 mg/kg IV q12 hours
  • References
  1. Allington (2001) Clin Ther 23(1):24-44 [PubMed]
  2. Lamb (1999) Drugs 58(6):1061-97 [PubMed]
  3. Lundstrom (2000) Infect Dis Clin North Am 14(2):463-74 [PubMed]
  4. Manzella (2001) Am Fam Physician 64(11):1863-6 [PubMed]
  5. Paradisi (2001) Med Clin North Am 85(1):1-17 [PubMed]