Pharm

Quinupristin-Dalfopristin

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Quinupristin-Dalfopristin, Synercid, Streptogramin

  1. Vancomycin-resistant Enterococcus
  2. Methicillin susceptible Staphylococcus aureus
  3. Methicillin susceptible Streptococcus Pyogenes
  • Mechanism
  1. Bacterial 50S Ribosome
  2. Resistance rare
  • Pharmacokinetics
  1. Hepatic Clearance predominates
  2. Half-Life: 1-3 hours (9-10 hours of affect)
  • Adverse Effects
  1. Arthralgias or myalgias
  2. Nausea, Diarrhea or Vomiting
  3. Rash or Pruritus
  4. Headache
  1. Raises serum drug levels of substrates in 3A4 system
  2. Follow Cyclosporine levels when using concurrently
  • Dosing
  1. Enterococcus faecium: 7.5 mg/kg IV q8 hours
  2. Severe Skin Infections: 7.5 mg/kg IV q12 hours
  • References
  1. Allington (2001) Clin Ther 23(1):24-44 [PubMed]
  2. Lamb (1999) Drugs 58(6):1061-97 [PubMed]
  3. Lundstrom (2000) Infect Dis Clin North Am 14(2):463-74 [PubMed]
  4. Manzella (2001) Am Fam Physician 64(11):1863-6 [PubMed]
  5. Paradisi (2001) Med Clin North Am 85(1):1-17 [PubMed]