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Paromomycin

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Paromomycin

  • See Also
  1. Aminoglycoside
  2. Amebiasis
  3. Giardiasis
  • Indications
  1. Amebiasis (intestinal)
  2. Giardiasis (off-label)
  • Mechanism
  1. Aminoglycoside (Oligosaccharide) Antibiotic derived from Streptomyces species
  2. Specifically binds RNA oligonucleotide at the A site of Bacterial 30S ribosomes
    1. Results in misreads and premature termination of translation
    2. Inhibits Protein synthesis, leading to cell death
  • Dosing
  1. Take with food or after meals
  2. Amebiasis (Adults and Children)
    1. Paromomycin 25 to 35 mg/kg/day orally divided three times daily for 5 to 10 days
  3. Giardiasis (off-label) for adults and children)
    1. Adult: 500 mg orally three times daily for 7 days
    2. Child: 25 to 35 mg/kg/day orally divided three times daily taken for 7 days
  • Pharmacokinetics
  1. Not absorbed
    1. Absorption may occur in Inflammatory Bowel Disease, and secondary nephrotoxicity may occur
  • Safety
  1. Not absorbed
  2. May be used in Lactation
  3. Pregnancy
    1. Unknown safety in first trimester
    2. May be used in later pregnancy
  • Resources
  1. Paromomycin Capsule (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cc0f4113-e627-4caf-b2d4-95b4106e57f5