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Penicillin G Procaine

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Penicillin G Procaine, Procaine Penicillin

  • See Also
  1. Natural Penicillin
  2. Penicillin
  • Indications
  1. Erysipeloid
  2. Pneumococcal Infections
  3. Streptococcal Infections
  4. Acute Necrotizing Ulcerative Gingivitis (ANUG or Vincent's Stomatitis)
  5. Neurosyphilis
  6. Congenital Syphilis
  7. Diphtheria
  • Contraindications
  • ` Penicillin or Procaine Allergy
  1. Do NOT inject intravenously
  • Mechanism
  1. See Penicillin
  2. See Natural Penicillin for activity spectrum
  • Precautions
  1. Largely replaced by other agents due to Antibiotic Resistance
  2. Listed for historical purposes
  • Dosing
  1. Erysipeloid, Pneumococcal Infections, Streptococcal Infections and ANUG
    1. Adult (or weight >27 kg): 0.6 to 1 Million Units IM daily
    2. Child (weight <27 kg)
      1. Give 0.3 Million Units IM daily OR
      2. Give 25,000 to 50,000 units/kg/day IM divided in 1-2 doses for moderate infections in age >1 month
  2. Diphtheria
    1. Adult (and weight >10 kg): 0.6 Million units IM every 12 hours until transition to oral Penicillin VK for 14 days
    2. Child (weight <10 kg): 0.3 Million units IM every 12 hours until transition to oral Penicillin VK for 14 days
  3. Neurosyphilis (Adult)
    1. Give 2.4 Million Units IM daily WITH Probenacid 500 mg every 6 hours for 10 to 14 days
  4. Congenital Syphilis (Child)
    1. Give 50,000 units/kg IM daily for 10 days
  • Pharmacokinetics
  1. Peaks in 4 hours
  2. Duration: 24 hours
  • Adverse Effects
  1. See Penicillin
  • Safety
  1. Considered safe in pregnancy
  2. Considered safe in Lactation
  • Resources
  1. Procaine Penicillin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07fe2b47-34ac-4a20-be67-3c788c77b207
  • References
  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 104-7
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  3. Bush (2016) Cold Spring Harb Perspect Med 6(8):a025247 +PMID: 27329032 [PubMed]
  4. Miller (2002) J Midwifery Womens Health 47(6):426-34 +PMID: 12484664 [PubMed]