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Penicillin G Benzathine

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Penicillin G Benzathine, Benzathine Penicillin, Bicillin LA

  • See Also
  1. Natural Penicillin
  2. Penicillin
  • Indications
  1. Group A Streptococcal Pharyngitis
  2. Syphilis
  3. Diphtheria
  • Contraindications
  1. Do NOT inject intravenously (potentially lethal)
  2. Not adequate for Neurosyphilis treatment
  • Mechanism
  1. See Penicillin
  2. Semisynthetic, long-acting benzathine salt of Penicillin G
  3. See Natural Penicillin for activity spectrum
  • Dosing
  1. General
    1. Inject deep IM into upper outer buttock, or in children, inject into the mid-lateral thigh
  2. Group A Streptococcal Pharyngitis
    1. Weight <27 kg: 0.6 Million Units IM for 1 dose
    2. Weight >27 kg: 1.2 Million Units IM for 1 dose
  3. Syphilis
    1. Adult: 2.4 Million Units IM
    2. Child: 50,000 Units/kg up to 2.4 Million Units IM
    3. Timing
      1. Primary, Secondary or early Latent Syphilis: Give single dose at diagnosis
      2. Tertiary or late Latent Syphilis: Repeat dose weekly for a total of 3 weeks
        1. Not adequate coverage for Neurosyphilis
  4. Diphtheria Prophylaxis and Carrier Treatment
    1. Weight <30 kg: 0.6 Million Units IM for 1 dose
    2. Weight >30 kg: 1.2 Million Units IM for 1 dose
  • Adverse Effects
  1. See Penicillin
  • Safety
  1. Considered safe in pregnancy
  2. Considered safe in Lactation
  • Resources
  1. Penicillin G Benzathine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=012d46f1-d0a0-4676-a879-cd320297ab16
  • References
  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 104-7
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  3. Bush (2016) Cold Spring Harb Perspect Med 6(8):a025247 +PMID: 27329032 [PubMed]
  4. Miller (2002) J Midwifery Womens Health 47(6):426-34 +PMID: 12484664 [PubMed]