Pharm

Mupirocin

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Mupirocin, Bactroban

  • See Also
  1. Topical Antibiotic
  2. Impetigo
  • Indications
  1. Impetigo
  2. MRSA nasal carriage
  • Mechanism
  1. Topical Antibiotic extracted from Pseudomonas fluorescens
  2. Inhibits Bacterial Protein synthesis
    1. BInds reversibly and specifically to Bacterial isoleucyl tRNA synthase
  3. Active against Gram Positive Bacteria, Streptococcus and Staphylococcus (including MRSA)
  • Dosing
  1. May be used in age 2 months and older
  2. Available as 22 g tube (ointment is less expensive than creams)
  3. Impetigo
    1. Apply Mupirocin 2% ointment three times daily to affected area for 7-10 days
  • Efficacy
  1. Emerging Streptococcal resistance in 2014
  • Resources
  1. Mupirocin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ff7428fb-9ce9-4743-b58c-01a05424a57a