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Dalbavancin

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Dalbavancin, Dalvance

  • See Also
  1. Glycopeptide Antibiotic
  2. Oritavancin
  • Indications
  1. See Glycopeptide Antibiotic
  2. Refractory Skin and Soft Tissue Infections with failure to respond to maximal oral antibiotic coverage
  • Mechanism
  1. See Glycopeptide Antibiotic
  2. Decreases Bacterial cell wall synthesis
  3. Similar coverage and mechanism to Vancomycin
  4. Long-acting agents, with a single Parenteral dose covering entire antibiotic course
  • Dosing
  • Adult Standard
  1. Adults - Single Dose Regimen
    1. Give 1500 mg IV once over 30 minutes
  2. Adults - Two Dose Regimen (one week apart)
    1. Dose One: 1000 mg IV over 30 minutes
    2. Dose Two: 500 mg IV over 30 minutes given at one week after first dose
  • Dosing
  • Adult Renal (eGFR <30 ml/min)
  1. General
    1. Hemodialysis does not remove Dalbavancin (may be given regardless of Hemodialysis timing)
  2. Adults - Single Dose Regimen
    1. Give 1125 mg IV once over 30 minutes
  3. Adults - Two Dose Regimen (one week apart)
    1. Dose One: 750 mg IV over 30 minutes
    2. Dose Two: 375 mg IV over 30 minutes given at one week after first dose (if not on Hemodialysis)
  • Disadvantages
  1. Expensive ($2500 to $9500 per single dose)
  • Safety
  1. Unknown Safety in Pregnancy
  2. Unknown Safety in Lactation
  • Resources
  1. Dalbavancin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4b4674d8-4d1e-4728-8465-d42ada33fa5c
  • References
  1. (2014) Presc Lett 21(8): 43