Lab

Platelet Morphology on Peripheral Smear

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Platelet Morphology on Peripheral Smear, Platelet Morphology

  • See Also
  1. Peripheral Smear
  2. Bone Marrow Aspirate
  3. Thrombocytopenia
  4. Platelet Count
  5. Complete Blood Count
  6. Mean Platelet Volume
  7. Platelet Function Closure Time
  • Evaluation
  1. Variants below as seen on Peripheral Smear
  2. Confirm Platelet Count
    1. Oil Immersion at 1000x Magnification
    2. Typical count: 15-20 per field
  3. Scan the slide for Platelet clumping (platelet Agglutination)
    1. Associated with EDTA-activated antiplatelet antibodies
    2. Electronic undercounting (Pseudothrombocytopenia)
    3. Repeat sample in non-EDTA Anticoagulant
  1. Megathrombocytes (Platelet >2.5 microns diameter)
    1. Accelerated Platelet production
    2. Compensation fro increased Platelet destruction
    3. Vitamin B12 Deficiency
    4. Myeloproliferative diseases
    5. Congenital Thrombocytopenia (e.g. Bernard-Soulier Syndrome)
    6. Immune Thrombocytopenic Purpura
  2. Megakaryocyte Fragments
    1. Myelofibrosis
  3. Platelet hypogranularity
    1. Myelodysplastic Syndrome
    2. Myelofibrosis