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Progestin Endometrial Activity

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Progestin Endometrial Activity, Endometrial Activity

  • See Also
  1. Oral Contraceptive
  2. Progestin
  • General
  1. Ability to prevent spotting or breakthrough bleeding
  2. Dependent on Estrogen-Progestin ratio
  3. Bleeding may be due to:
    1. Estrogen insufficiency
    2. Progesterone insufficiency
  • Progestins with least potent Endometrial Activity
  1. Amount to suppress bleeding for 20 days in 50% women
  2. Gestodene (12.6)
  3. Desogestrel (8.7)
  4. Levonorgestrel (5.1)
  5. dl-Norgestrel (2.6)
  • Progestins with most Endometrial Activity
  1. Amount to suppress bleeding for 20 days in 50% women
  2. Norethynodrel (0): Low limit reference
  3. Norethindrone Acetate (0.4)
  4. Ethynodiol Diacetate (0.4)
  5. Norethindrone (1.0)
  • Oral Contraceptives with least Endometrial Activity
  1. Least suppression of bleeding
  2. Progestin-Only (Mini-Pill)
  3. Demulen 1/35
  4. Loestrin
  5. Tri-Norinyl
  • Oral Contraceptives with most Endometrial Activity
  1. Greatest suppression of bleeding
  2. Ovral
  3. Lo-Ovral
  4. Ortho Novum
  5. Ovcon
  6. Norlestrin
  7. Demulen 50
  • References
  1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
  2. Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
  3. Dickey (1998) Managing Contraceptive Pill Patients