Pharm
Progestin Endometrial Activity
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Progestin Endometrial Activity
, Endometrial Activity
See Also
Oral Contraceptive
Progestin
General
Ability to prevent spotting or breakthrough bleeding
Dependent on
Estrogen
-
Progestin
ratio
Bleeding may be due to:
Estrogen
insufficiency
Progesterone
insufficiency
Progestins with least potent Endometrial Activity
Amount to suppress bleeding for 20 days in 50% women
Gestodene
(12.6)
Desogestrel
(8.7)
Levonorgestrel
(5.1)
dl-
Norgestrel
(2.6)
Progestins with most Endometrial Activity
Amount to suppress bleeding for 20 days in 50% women
Norethynodrel
(0): Low limit reference
Norethindrone Acetate
(0.4)
Ethynodiol Diacetate
(0.4)
Norethindrone
(1.0)
Oral Contraceptives with least Endometrial Activity
Least suppression of bleeding
Progestin
-Only (
Mini-Pill
)
Demulen 1/35
Loestrin
Tri-Norinyl
Oral Contraceptives with most Endometrial Activity
Greatest suppression of bleeding
Ovral
Lo-Ovral
Ortho Novum
Ovcon
Norlestrin
Demulen 50
References
Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
Dickey (1998) Managing Contraceptive Pill Patients
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