Pharm

Trimethobenzamide

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Trimethobenzamide, Tigan

  • Indications
  1. Emesis of central cause
  • Mechanism
  1. Centrally acting non-Phenothiazine Antiemetic
  2. Dopamine 2 Antagonist
    1. Active at the ChemoreceptorTrigger Zone in the Medulla of the Brainstem
  • Dosing
  1. Adults
    1. Dose: 300 mg orally or 200 mg IM every 6 to 8 hours
  2. Child (15 to 41 kg)
    1. Dose: 100-200 mg orally three to four times daily
  3. Child (<15 kg): Avoid
  • Safety
  1. Pregnancy Category C
  2. Unknown safety in Lactation
  3. Reduce dose in renal dysfunction and older patients
  • Resources
  1. Trimethobenzamide (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8ccb7a57-a1e4-55f7-e053-2a95a90a792b
  • References
  1. Johnson (1993) Harriet Lane, Mosby, p. 521
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia