Pharm

Tenapanor

search

Tenapanor, Ibsrela

  • Indications
  1. Constipation Dominant Irritable Bowel Syndrome
  • Contraindications
  1. Mechanical Bowel Obstruction
  2. Children (esp. age < 6 years)
    1. Increased risk of severe Dehydration
  • Mechanism
  1. Locally acting Sodium-Hydrogen exchanger 3 Inhibitor (NHE3 Inhibitor)
    1. Increases intestinal fluid secretion
  • Dosing
  1. Very expensive ($1500/month in 2022)
  2. Take 50 mg orally twice daily immediately before breakfast and supper
  • Efficacy
  1. May reduce Abdominal Pain and improve stool frequency (NNT 9 to 12)
    1. Similar efficacy as Lubiprostone and Linaclotide
  • Adverse Effects
  1. Abdominal Distention
  2. Flatulence
  3. Dizziness
  4. Diarrhea (16% of cases, severe in 2.5% of cases)
    1. Hold for severe Diarrhea
  • Resources
  1. Tenapanor (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2102da5f-a1a0-4ac7-a1f6-38698cf7273a
  • References
  1. (2022) Presc Lett 29(6): 36
  2. Curtis (2022) Am Fam Physician 105(6): 656-8
  3. (2021) Irritable Bowel Syndrome Drug Comparison, Presc Lett, #370305
  4. (2020) Med Lett Drugs Ther 62(1594): 41-58