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Plecanatide

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Plecanatide, Trulance

  • See Also
  1. Constipation Dominant Irritable Bowel Syndrome
  2. Chronic Constipation
  3. Lubiprostone
  4. Linaclotide
  • Indications
  1. Constipation Dominant Irritable Bowel Syndrome
  2. Chronic Idiopathic Constipation
  • Contraindications
  1. Mechanical Bowel Obstruction
  2. Children (esp. age < 6 years)
    1. Increased risk of severe Dehydration
  • Mechanism
  1. Guanylate cyclase-c Agonist
  2. Induces cGMP mediated chloride and bicarbonate secretion into bowel lumen; Sodium and water follow
    1. Results in gastrointestinal fluid secretion into the bowel lumen (secretagogue)
  • Dosing
  1. Take 3 mg orally daily
  • Efficacy
  1. May improve stool frequency, consistency and straining in Irritable Bowel Syndrome
  • Adverse Effects
  1. Diarrhea
    1. Hold Linaclotide for severe Diarrhea
  • Safety
  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation
  • Drug Interactions
  1. No known Drug Interactions
  • Resources
  1. Plecanatide (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f1766455-79a2-409f-9325-0e3d6743acc7
  • References
  1. (2021) Irritable Bowel Syndrome Drug Comparison, Presc Lett, #370305
  2. (2020) Med Lett Drugs Ther 62(1594): 41-58