Pharm

Olsalazine

search

Olsalazine, Dipentum

  • See Also
  1. Balsalazide
  • Indications
  1. Ulcerative Colitis
  • Mechanism
  1. Diazo-Bonded 5-ASA product
  2. Olsalazine is a prodrug that is retained in the colon and metabolized to 5-Aminosalicylic Acid
    1. Oral agent converted to active 5-ASA (Mesalamine) by Bacteria within the colon
  • Dosing
  • Adult
  1. Induction: 1.5 to 3 g/day divided twice daily
  2. Maintain: 500 mg orally twice daily with food
    1. As of 2022, >$1500/month
  • Adverse Effects
  1. Diarrhea (17 to 20%)
    1. Balsalazide has similar mechanism of action, but less Diarrhea (better tolerated)
  • Safety
  1. Pregnancy Category C
  2. Avoid in Lactation
  • Resources
  1. Olsalazine - Dipentum (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8512d0c6-db4e-4673-b3b4-28975c18413f
  • References
  1. (2022) Treatment of Mild to Moderate Ulcerative Colitis, Presc Lett, #350406
  2. (2023) Drugs for Inflammatory Bowel Disease, Med Lett Drug Ther 65: 105-12