Pharm

Fecal Transfer

Fecal Transfer, Stool Transplant, Fecal Bacteriotherapy, Fecal Microbiota Transplantation, Intestinal Microbiota Transplant, Vowst, Rebyota

Healthy donor (e.g. spouse or stool bank) with normal fecal flora
1. Stool bank sources typically cost $1700 per dose
2. Donors are screened for infectious disease (e.g. HIV Infection)
Rebyota
1. FDA approved product, $9000 per dose on release in 2023
2. Contains fecal microbiota from pooled sources screened for infectious disease
3. Introduced via rectal enema
Vowst
1. FDA approved for preventing C. difficile recurrence, $17,500 for a 3 day course in 2023
2. Taken orally by patient at home (without Nasogastric Tube)
3. Contains only spores and does not require refrigeration

General (all preparations)
1. C. difficile Antibiotics should be completed at least 2 to 4 days prior to dose
2. Avoid systemic Antibiotics for at least 8 weeks after dose
Donor transplants
1. Single dose sample typically introduced via Nasogastric Tube or similar
2. Small volume fecal amount (25 grams) sufficient to reestablish normal flora
Vowst
1. Laxative (choose one) taken 1 day prior to starting 3 day course
  1. Magnesium Citrate 10 oz (included in Vowst kit) OR
  2. Polyethylene Glycol Solution 250 ml