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Toxic Hepatitis

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Toxic Hepatitis, Drug-Induced Hepatitis, Drug Induced Liver Injury

  • See Also
  1. Hepatotoxin
  2. Acute Hepatitis
  3. Acute Liver Failure
  1. Signs
    1. Biopsy with necrosis at terminal hepatic venule
  2. Causes
    1. See Hepatotoxin
    2. Carbon tetrachloride
    3. Benzene derivative
    4. Mushroom Poisoning
    5. Herbal Toxicity
    6. Antiepileptics
    7. Amiodarone
    8. Methotrexate
    9. Acetaminophen (42% of acute liver injury in U.S.)
      1. See Acetaminophen Toxicity
    10. Antibiotics (second most common cause in U.S.)
      1. Amoxicillin-clavulanate
      2. Trimethoprim-sulfamethoxazole
      3. Isoniazid
      4. Nitrofurantoin
  • Types
  • Idiosyncratic Reaction (Variable onset)
  1. Signs
    1. Fever
    2. Rash
    3. Arthralgia
    4. Eosinophilia
  2. Causes
    1. Isoniazid
    2. Halothane
    3. Phenytoin
    4. Methyldopa
  • Resources
  1. See Hepatotoxin
  2. NIDDK/NLM Liver Tox
    1. http://www.livertox.nih.gov
  • References
  1. Reuben (2010) Hepatology 52(6): 2065-76 [PubMed]