IBD

Extraintestinal Manifestations of Inflammatory Bowel Disease

Extraintestinal Manifestations of Inflammatory Bowel Disease, Extraintestinal Manifestations of Crohn's Disease, Extraintestinal Manifestations of Ulcerative Colitis, Musculoskeletal Manifestations of Inflammatory Bowel Disease, Ocular Manifestations of Inflammatory Bowel Disease, Dermatologic Manifestations of Inflammatory Bowel Disease, Hepatobiliary Manifestations of Inflammatory Bowel Disease

See Also

Background

Ulcerative Colitis and Crohns Disease share similar extraintestinal manifestations
However extraintestinal findings are more common with Crohn's Disease

Associated Conditions
Musculoskeletal

Osteoporosis (15% of UC, >2% of CD)
Inflammatory Arthropathy, Colitic Arthritis or Arthralgias (5-21% of UC, >10% of CD)
Ankylosing Spondylitis (2% of UC)

Associated Conditions
Ocular

Episcleritis (parallels Ulcerative Colitis course, occurs in 29% of CD)
Scleritis (18% of CD)
Anterior Uveitis (3-4% of UC, 17% of CD)
1. Variable course
2. Associated with Enteropathic Arthritis
Recurrent Iritis

Associated Conditions
Dermatologic

Digital Clubbing (presence increases likelihood of Ulcerative Colitis)
Erythema Nodosum (3% of UC, >2% of CD)
1. Parallels Ulcerative Colitis course
Pyoderma Gangrenosum (up to 2% of UC, >0.5% of CD)
Lichen Planus
Aphthous Stomatitis, Aphthous Ulcers or Canker Sores (4% of UC)
Psoriasis (1% of UC)

Associated Conditions
Hepatobiliary

Hepatic Steatosis
Primary Sclerosing Cholangitis (4-5% co-Incidence in UC)
1. Occurs in as many as 2.5 to 7.5% of Ulcerative Colitis patients
2. Progresses to Cirrhosis and liver failure in most patients
Cholelithiasis (>13% in CD)
Pericholangitis

Associated Conditions
Miscellaneous

See Gynecologic Manifestations of Crohn's Disease
Anemia (>9% of CD)
Aphthous Stomatitis (>4%)
Nephrolithiasis and Ureteral Stones (>8% of CD)
Venous Thromboembolism (DVT/PE in 0.3% of UC, >10% of CD)
1. Deep Vein Thrombosis or Pulmonary Embolism in 0.3% of UC cases

References