Exam

Maddrey Discriminant Function

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Maddrey Discriminant Function

  • Indications
  1. Acute Alcoholic Hepatitis Prognosis
  • Calculation
  1. Discriminant function = 4.6 x (PTa - PTc) + Bili
  2. Where
    1. PTa: Actual ProTime (PT) in seconds
    2. PTc: Normal ProTime (PT) in seconds (typically 11-13 s)
    3. Bili: Serum Bilirubin in mg/dl
  • Interpretation
  1. Discriminant result >32 is associated with severe disease and a 1 month mortality >50%