Exam

Fibrosis Probability Score

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Fibrosis Probability Score, FIB-4 Index

  • Indications
  1. Hepatitis B risk for fibrosis
  2. Nonalcoholic Fatty Liver Disease assessment for Fibrosis (NASH)
  • Criteria
  1. Score = (Age x AST) / (

    x sqrRoot(ALT))

  • Interpretation
  1. Score <1.45: Good Negative Predictive Value (80% for Hepatitis CVirus related fibrosis)
  2. Score >3.25 (>2.67 in NAFLD): Positive Predictive Value >80%
  • Efficacy
  1. Test Sensitivity: 85%
  2. Test Specificity: 65%
  • References
  1. Mallet (2009) Aliment Pharmacol Ther 15;29(4):409-15 +PMID: 19035983 [PubMed]