Pharm

Sulfonylurea

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Sulfonylurea, Insulin Secretagogue

  • See Also
  1. Oral Hypoglycemic Agents
  • Background
  1. Discovered in 1940's when investigating antibiotics
  • Mechanism
  1. Stimulates Potassium channel closure on pancreatic beta cell surface
  2. Results in Insulin release
  • Types
  1. First Generation Sulfonylurea (Listed for historical purposes only)
  2. Second Generation Sulfonylurea (e.g. Glipizide, Glyburide)
  3. Non-Sulfonylurea Insulin Secretagogues (e.g. Meglitinide, Repaglinide)