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Cortisone

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Cortisone

  • See Also
  1. Systemic Corticosteroid
  2. Topical Corticosteroid
  3. Inhaled Corticosteroid
  4. Intranasal Steroid
  5. Intra-articular Corticosteroid
  6. Corticosteroid Associated Osteoporosis
  7. Stress Dose Steroid
  8. Steroid-Induced Hyperglycemia
  • Indications
  1. Adrenal Insufficiency
  • Mechanism
  1. See Systemic Corticosteroid
  2. Cortisone is a naturally occurring steroid Hormone produced in the Adrenal Gland
  3. Cortisone is hydroxylated to the active Cortisol by the enzyme 11-beta-steroid dehydrogenase
  • Medications
  1. Cortisone (Cortone) tablets 25 mg
  1. Adult: 25 to 300 mg orally daily
  2. Child (not FDA approved): 0.5 to 0.75 mg/kg/day orally divided every 8 hours
  • Pharmacokinetics
  1. Low potency
  2. Low anti-inflammatory potency
  3. Has Mineralocorticoid Activity
  4. Short Half-Life (8-12 hours)
  • Adverse Effects
  1. See Systemic Corticosteroid
  • Safety
  1. See Systemic Corticosteroid
  2. Pregnancy Category D
  3. Avoid in Lactation
  • References
  1. Swadron and Hope in Herbert (2018) EM:Rap 18(9):16-8
  2. Dvorin (2020) Am Fam Physician 101(2): 89-94 [PubMed]
  3. Lane (1998) Endocrinol Metab Clin North Am 27:465-83 [PubMed]