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Drug-Induced Bullous Disease

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Drug-Induced Bullous Disease

  • See Also
  1. Bullous Disease
  2. Life-Threatening Drug-Induced Rashes
  3. Adverse Drug Reaction
  4. Hypersensitivity Reaction
  5. Anaphylaxis
  6. Penicillin Allergy
  7. Gell and Coombs Classification
  8. Fixed Drug Eruption
  • Signs
  1. Variable, insidious onset from time of offending medication exposure
  2. Variable distribution (may occur anywhere)
  3. Bullae of variable consistency (tense or flaccid) and size (large or small)
  4. Erosions (unroofed bullae)
  • Causes
  1. ACE Inhibitors
  2. Beta-lactam Antibiotics (Penicillins, Cephalosporins, Carbapenems)
  3. Calcium Channel Blockers
  4. Furosemide (Lasix)
  5. Vancomycin
  • Differential Diagnosis
  1. See Bullous Disease
  2. Bullous Pemphigoid
  3. Pemphigus
  • Management
  1. Eliminate offending agent
  2. Consider Corticosteroids
  • References
  1. Jhun and DeClerck in Herbert (2015) EM:Rap 15(2): 9-11