Blister

Pemphigus

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Pemphigus, Intraepidermal Blister

  • See Also
  1. Bullous Disease
  2. Pemphigoid
  • Definition
  1. Intraepidermal Acantholytic Blister
  2. Mnemonic: Pemphigus ends in S for Superficial
    1. Contrast with the deeper Pemphigoid
  • Types
  • Primary forms of Pemphigus
  1. Deep Pemphigus (above Basal Cell Layer of Epidermis)
    1. Pemphigus Vulgaris (most common and most severe)
    2. Pemphigus Vegetans (rare Pemphigus Vulgaris variant)
    3. Drug-Triggered Pemphigus (umasks Pemphigus Vulgaris)
  2. Superficial Pemphigus (involves Stratum Granulosum)
    1. Pemphigus Foliaceus
    2. Pemphigus erythematosus (Senear-Usher Syndrome)
    3. Pemphigus herpetiformis
    4. Fogo selvagem
    5. Pemphigus
  • Types
  • Secondary forms of Pemphigus
  1. Paraneoplastic Pemphigus
  2. Drug-Induced Pemphigus (similar to Pemphigus Foliaceus)
  • Signs
  1. Flaccid Blister (superficial)
  2. Nikolsky's Sign
    1. Positive in Pemphigus Vulgaris
    2. Negative in Pemphigus Foliaceus (most superficial)
  • Histology
  1. All Pemphigus conditions show epidermal Acantholysis