Blister
Pemphigus Vegetans
search
Pemphigus Vegetans
, Familial Benign Pemphigus, Hailey-Hailey Disease
Epidemiology
Autosomal Dominant
inherited condition
Pathophysiology
Benign variant of
Pemphigus Vulgaris
Suprabasal cell
Acantholysis
Exacerbating factors
Superficial
Bacterial Infection
Warm weather
Signs
Mouth mucosal lesions absent
Large confluent vegetative
Skin Erosion
s
Center with moist granular tissue
Border composed of
Vesicle
s and
Pustule
s
Distribution
Form in intertriginous areas (groin, axillae)
Also affects neck folds and scalp or face
Labs
Immunofluorescence shows no antibodies on biopsy
Management
Treat local infections
Consider topical and systemic
Antibiotic
s
Consider
Antifungal
agents for candida infection
Surgical excision of large vegetative growths
Course
Much better prognosis than
Pemphigus Vulgaris
References
Parker in Goldman (2000) Cecil Medicine, p. 2284
Cotell (2000) Am J Emerg Med 18(3):288-99 [PubMed]
Type your search phrase here