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Acute Generalized Exanthematous Pustulosis

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Acute Generalized Exanthematous Pustulosis, AGEP

  • See Also
  1. Life-Threatening Drug-Induced Rashes
  2. Adverse Drug Reaction
  3. Hypersensitivity Reaction
  4. Anaphylaxis
  5. Penicillin Allergy
  6. Gell and Coombs Classification
  7. Fixed Drug Eruption
  • Pathophysiology
  1. Adverse Drug Reaction
  • Symptoms
  1. Rash onset within four days of offending medication exposure
  • Signs
  1. Fever
  2. Rash
    1. Onset at flexor surfaces (e.g. neck, axilla, antecubital fossa, popliteal fossa)
    2. Tiny, non-follicular Pustules
  • Causes
  1. Beta-lactam antibiotics (Penicillins, Cephalosporins, Carbapenems)
  2. Macrolide antibiotics (e.g. Erythromycin, Azithromycin)
  3. Calcium Channel Blockers
  • Labs
  1. Complete Blood Count
    1. Leukocytosis
    2. Neutrophilia
  • Management
  1. Eliminate the offending agent
  2. Consider Topical Corticosteroids
  • References
  1. Jhun and DeClerck in Herbert (2015) EM:Rap 15(2): 9-11