Pharm

Tazarotene

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Tazarotene, Tazorac

  • See Also
  1. Acne Vulgaris Pharmacologic Management
  • Indications
  1. Psoriasis
    1. Primary use
  2. Acne Vulgaris
    1. Other Comedolytics are better tolerated (Retin A, Adapalene)
  • Mechanism
  1. Retinoid
  2. Suppresses epidermal thickening, Scaling
  • Preparations
  1. Cream 0.05%, 0.1%
  2. Gel 0.05%, 0.1%
  • Dosing
  1. Applied each day
  2. Quick onset of benefit
  3. Start at 0.05% gel, may advance to 0.1% gel
  • Efficacy
  1. Under 50% have moderate to marked benefit
  2. Best used in combination with topicals
  3. Benefit may last for several weeks after stopping
  • Adverse Effects
  1. Local irritation is common
    1. Erythema in almost everyone
    2. Peeling and dryness
    3. Pruritus, stinging and burning
    4. Not tolerated by 10% of patients
  2. Risk of Koebner Reaction
    1. Results in larger area Psoriasis
    2. Apply strictly to lesion
  • Safety
  1. Pregnancy Category X