Pharm

Differin

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Differin, Adapalene, Epiduo

  • See Also
  1. Acne Vulgaris Pharmacologic Management
  • Indication
  1. Acne Vulgaris
  • Mechanism
  1. Comedolytic
  2. Synthetic Retinoid analog
  • Supplied
  1. Adapalene only
    1. Gel 0.1% (Over-the-counter in U.S. as of 2017)
    2. Gel 0.3%
    3. Cream 0.1%
    4. Lotion 0.1%
  2. Combinations
    1. Adapalene/Benzoyl Peroxide 0.1%/2.5% gel (Epiduo)
    2. Adapalene/Benzoyl Peroxide 0.3%/2.5% gel (Epiduo Forte)
  • Adverse Effects
  1. Same as Tretinoin, but less severe
  • Safety
  1. Pregnancy Category C
    1. But generally recommended to avoid in pregnancy (esp. first trimester)
  • Efficacy
  1. As effective as Tretinoin (Retin-A)
  2. Better tolerated than Tretinoin (less irritation)
  3. Generic and cost (2019) is $20 for 45 grams
  • Reference
  1. (1997) Med Lett Drugs Ther, 39:19-20 [PubMed]