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Medication Causes of Hyperpigmentation

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Medication Causes of Hyperpigmentation, Hyperpigmentation Due to Medication, Drug Induced Hyperpigmentation

  • Causes
  1. Heavy Metals
    1. Arsenic
    2. Bismuth
    3. Gold
    4. Mercury
    5. Silver
  2. Cardiovascular Agents
    1. Amiodarone
    2. Quinidine
  3. Neuropsychiatric agents
    1. Methyldopa
    2. Amitriptyline (Elavil)
  4. Chemotherapy
    1. Bleomycin
    2. Busulfan
    3. Cyclophosphamide
    4. Daunorubicin
    5. Dibromomannitol
    6. Doxorubicin
    7. Tacrolimus (Prograf)
    8. Topical nitrogen mustard
  5. Antimicrobials
    1. Chloroquine
    2. Clofazimine
    3. Hydroxychloroquine (Plaquenil)
    4. Ketoconazole
    5. Minocycline (and less commonly with other Tetracyclines)
    6. Zidovudine
  6. Miscellaneous
    1. Oral Contraceptives or Hormone Replacement Therapy
    2. Phenothiazines