Pharm

Ciclopirox

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Ciclopirox, Loprox, Penlac

  • See Also
  1. Topical Antifungal
  2. Onychomycosis
  • Indications
  1. Dermatophyte Infection (Tinea Corporis, Tinea Pedis, Tinea Cruris)
  2. Cutaneous Candidiasis
  3. Tinea Versicolor
  4. Onychomycosis
    1. Not recommended (low efficacy and a very long course)
  • Mechanism
  1. Broad-spectrum Antifungal activity
  2. Antifungal for dermatophytes and yeast
  3. Some antibacterial activity in vitro
    1. Gram Positive Bacteria
    2. Gram Negative Bacteria
  • Medications
  1. Cutaneous dermatophytes
    1. Ciclopirox Shampoo 1% (Loprox)
    2. Ciclopirox Lotion, Cream or Gel: 0.77%
  2. Onychomycosis (Penlac)
    1. Ciclopirox 8% lacquer (Penlac)
  • Dosing
  • Adults and Age >12 years old
  1. Dermatophyte Infection (Tinea Corporis, Tinea Pedis, Tinea Cruris, Tinea Versicolor) and Cutaneous Candidiasis
    1. Apply twice daily
  2. Onychomycosis (not recommended; low efficacy and a very long course)
    1. Apply daily to affected nails (over the top of prior application)
    2. Remove with Alcohol every 7 days
    3. Requires 48 week application
  3. Seborrheic Dermatitis
    1. Shampoo twice weekly for 4 weeks
    2. Avoid eye exposure to Shampoo
    3. Light colored hair may be discolored
  • Safety
  1. Pregnancy Category B
  2. Unknown safety in Lactation
  • Efficacy
  1. Tinea Pedis (Loprox)
    1. More effective than OTC Clotrimazole (Lotrimin)
  2. Onychomycosis (Penlac)
    1. NOT recommended
    2. Requires 48 week application
    3. Minimally better than Placebo for cure rates
    4. Partial clearance rates are also poor
  • Resources
  1. Ciclopirox 8% Lacquer Solution (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3ef301b7-c40a-0635-4a76-185141473dba
  2. Ciclopirox Shampoo (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=eef13684-751f-47e1-b75e-3401a0e6e20f
  3. Ciclopirox Olamine Cream (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?audience=consumer&setid=5c585aa5-7d2d-e798-c0bd-d602574d643c