Pharm

Ciclopirox

search

Ciclopirox, Loprox, Penlac

  • See Also
  1. Topical Antifungal
  • Indications
  1. Dermatophyte Infection (Tinea Corporis)
  2. Cutaneous Candidiasis
  3. Tinea Versicolor
  • Preparations
  1. Cutaneous dermatophytes: Ciclopirox olamine 1% (Loprox)
  2. Onychomycosis: Ciclopirox 8% lacquer (Penlac)
  • Mechanism
  • Broad-spectrum activity
  1. Antifungal for dermatophytes and yeast
  2. Some antibacterial activity in vitro
    1. Gram Positive Bacteria
    2. Gram Negative Bacteria
  • Efficacy
  1. Tinea Pedis (Loprox)
    1. More effective than OTC Clotrimazole (Lotrimin)
  2. Onychomycosis (Penlac)
    1. NOT recommended
    2. Requires 48 week application
    3. Minimally better than Placebo for cure rates
    4. Partial clearance rates are also poor