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Butenafine

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Butenafine, Mentax

  • See Also
  1. Topical Antifungal
  2. Tinea Infection
  3. Terbinafine
  • Indications
  1. Refractory cutaneous dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Cruris)
    1. Shorter course (2 instead of 4 weeks) than Clotrimazole
    2. More convenient (once daily) than other Topical Antifungals
  • Mechanism
  1. Naphthalenemethylamine derivative
  2. Benzylamine similar to allylamines (e.g. Terbinafine, Naftifine)
  • Dosing
  1. Apply once daily for 14 days to a 2 cm area surrounding Skin Infection
  2. Note: Unlike other Topical Antifungals, once daily application is sufficient
  • Efficacy
  1. High tinea cure rates with a 2 week course
  2. At 4-8 weeks, no significant difference in cure as compared with Clotrimazole
  • Safety
  1. Pregnancy Category B
  2. Unknown safety in Lactation
  • Resources
  1. Butenafine Hydrochloride 1% Cream (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=83830b24-bc94-4764-a6ca-3193abd9de66
  • References
  1. Greer (1997) J Am Acad Dermatol 37(2 Pt 1):231-5 [PubMed]
  2. Singal (2005) J Dermatolog Treat 16(5-6):331-5 [PubMed]