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Naftifine

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Naftifine, Naftin

  • See also
  1. Topical Antifungal
  2. Terbinafine (Lamisil)
  • Indications
  1. Resistant dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
    1. FDA approved in adults and children over age 12 years old
    2. As an exception, FDA approved for Tinea Cruris down to age >2 years
  • Mechanism
  1. Topical synthetic allylamine (similar to Terbinafine)
  2. Broad-spectrum Antifungal activity
  3. Blocks Ergosterol synthesis (key component in the fungal cell wall)
    1. Inhibits squalene epoxidase, the enzyme that converts squalene to ergosterol
  • Medications
  • Topical
  1. Naftifine HCl (Naftin)
    1. Cream: 1%, 2%
    2. Gel: 1%, 2%
  • Dosing
  1. Apply cream once daily (or gel twice daily) for up to 4 weeks
  • Safety
  1. Pregnancy Category B
  2. Unknown safety in Lactation
  • Efficacy
  1. Effective in refractory cases of superficial Tinea Infections
  2. Less effective in Cutaneous Candidiasis
  • Resources
  1. Naftifine Gel (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6371fceb-b98e-86a5-e053-2a91aa0a3d9e
  2. Naftifine Cream (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a740fc0d-45b3-411f-9dfd-f3d637b8a95f
  • References
  1. Monk (1991) Drugs 42(4):659-72 [PubMed]