- Resistant dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
- FDA approved in adults and children over age 12 years old
- As an exception, FDA approved for Tinea Cruris down to age >2 years
- Topical synthetic allylamine (similar to Terbinafine)
- Broad-spectrum Antifungal activity
- Blocks Ergosterol synthesis (key component in the fungal cell wall)
- Inhibits squalene epoxidase, the enzyme that converts squalene to ergosterol
- Naftifine HCl (Naftin)
- Cream: 1%, 2%
- Gel: 1%, 2%
- Apply cream once daily (or gel twice daily) for up to 4 weeks
- Pregnancy Category B
- Unknown safety in Lactation
- Effective in refractory cases of superficial Tinea Infections
- Less effective in Cutaneous Candidiasis
loading