Pharm

Fenoldopam

search

Fenoldopam, Corlopam

  • See Also
  1. Direct Acting Vasodilator
  2. Intravenous Antihypertensive
  3. Hypertensive Emergency
  4. Nitroprusside
  5. Hydralazine
  • Indications
  1. Hypertensive Emergency
  • Mechanism
  1. Benzapine derivative that acts primarily as a selective Dopamine Agonist at peripheral DA1 receptors
    1. Also act at alpha-2 adrenoreceptors
  2. Vasodilation and Antihypertensive activity
  3. Also increases Prolactin release
  4. Promotes Sodium and water diuresis via increased vasodilation and renal Blood Flow
  • Preparation
  1. Prepare 40 mcg/ml solution by diluting 10 mg in 250 ml D5W
  • Precautions
  1. Monitor Heart Rate and Blood Pressure closely (Intensive Care, emergency department)
  • Dosing
  • Adults
  1. Start 0.1 mcg/kg/min (11 ml/h for a 70 kg patient)
  2. Titrate as needed every 15 min to 0.1 to 1.6 mcg/kg/min
  • Dosing
  • Children
  1. Start 0.1 to 0.2 mcg/kg/min
  2. Titrate as needed every 20 to 30 min to 0.3 to 0.5 mcg/kg/min
  3. Maximum infusion rate: 0.8 mcg/kg/min
  4. Maximum duration: 4 hours
  • Adverse Effects
  1. Reflex Tachycardia
    1. More common with doses >0.1 mcg/kg/min
  2. Increased Intraocular Pressure
    1. Use caution in Glaucoma
  • Drug Interactions
  1. Avoid with Beta Blockers (higher risk of Hypotension)
  • Metabolism
  1. Half-Life: 5 minutes
  • Safety
  1. Pregnancy Category B
  2. Unknown safety in pregnancy
  • Resources
  1. Fenoldopam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=df4cd207-c3b8-4008-5290-02f296c2b4a6
  • References
  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia