Pharm
Apomorphine
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Apomorphine
, Uprima
Mechanism
Central acting,
Dopamine
rgic
Agonist
Pharmacokinetics
Onset: 10 minutes
Duration: 30 minutes
Dose
Uprima 2 to 6 mg SL
Efficacy
Effective in 55 to 60% of men (contrast 32% in
Placebo
)
Adverse Effects (58% of men on 6 mg)
Nausea
(39%)
Vomiting
(10%)
Dizziness
(20%)
Somnolence
(11%)
Sweaty (18%)
Hypotension
(4%)
Syncope
(2%)
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