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Rituximab

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Rituximab, Rituxan

  • See Also
  1. Monoclonal Antibody-Mediated Chemotherapy
  • Indications
  1. Refractory Rheumatoid Arthritis
  2. Non-Hodgkin's Lymphoma
  3. ANCA Vasculitis
  • Contraindications
  1. Do not use with live virus Vaccines
  • Mechanism
  1. Monoclonal Antibody to the CD20 Antigen that depletes CD20 positive B Cells
  • Dosing
  1. Rheumatoid Arthritis: 1 gram IV every 2 weeks for 2 doses
    1. Administered with Methylprednisolone 100 mg
  2. Non-Hodgkin's Lymphoma or ANCA Vasculitis: 375 mg/m2 IV weekly for 4 doses
  • Adverse Effects
  1. Severe infusion reactions (follows first infusion within 30-120 minutes)
  2. Tumor Lysis Syndrome
  3. Hepatitis B reactivation
  4. Renal Insufficiency
  • Monitoring
  1. PPD before initiating therapy
  2. Complete Blood Count at initiation of therapy and then periodically after