Pharm

Mycophenolate mofetil

search

Mycophenolate mofetil

  • Indications
  1. Refractory Rheumatoid Arthritis
  • Mechanism
  1. Mycophenolic acid (MPA) derivative
  2. Reversibly inhibits inosine monophosphate dehydrogenase (IMPDH)
  3. Primarily effects T Cell and B Cell proliferation and Antibody production
  • Dosing
  1. Dose: 500-1000 mg twice daily
  • Adverse effects
  1. Infection
  2. Malignancy (e.g. Skin Cancer, Lymphoma)
  3. Neutropenia
  4. Gastrointestinal Bleeding
  5. Nausea or Vomiting
  • Monitoring
  1. PPD before starting therapy
  2. Complete Blood Count
    1. Obtain baseline
    2. Obtain weekly for first month, twice monthly for next 2 months and then monthly