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Human Leukocyte Antigen B27

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Human Leukocyte Antigen B27, HLA-B27

  • See Also
  1. Major Histocompatibility Complex Antigen
  • Indications
  1. Limited use in clinical practice
  2. May be indicated if Ankylosing Spondylitis strongly suspected
  • Labs
  • Methods of Testing
  1. Antibody binding to patient's cells
  2. Mixed Lymphocyte responses against specific targets
  3. Hybridization to DNA probes
  • Efficacy
  1. Test Sensitivity for Spondyloarthropathy: 84%
  2. Test Specificity for Spondyloarthropathy: 96%
  1. Ankylosing Spondylitis: 95%
  2. Reiter's Syndrome (Reactive Arthritis): 80%
  3. Psoriatic Arthritis (Spondylitis with Psoriasis): 70%
  4. Enteropathic Arthritis (Spondylitis with Inflammatory Bowel Disease): 50%
  5. Incidence in general population without disease: 6-8%
  • References
  1. Gregersen in Ruddy (2001) Kelly's Rheumatology, p. 101
  2. Lane (2002) Am Fam Physician 65(6):1073-80
  3. Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]