• See Also
  1. Benzodiazepine
  • Class
  1. Long acting Benzodiazepine
  • Indications
  1. Insomnia
    1. Short-term use only
  • Dose
  1. Insomnia
    1. Start 7.5 orally at bedtime
    2. Maximum: 15 mg orally at bedtime (7.5 mg in the elderly)
  • Safety
  1. Pregnancy Category X (esp. first trimester)
  2. Avoid in Lactation
  3. Schedule IV Controlled Substance
  • Pharmacokinetics
  1. Half-Life: 39 hours
  • Metabolism
  1. Primarily metabolized by CYP3A4 to active metabolites
  2. Also metabolized by CYP2C9 and CYP2C19 to active metabolites
  • Resources
  1. Quazepam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9727e8b4-14f1-451d-9630-84eabc772e42
  • References
  1. (2019) Med Lett Drugs Ther 61(1578): 121-6
  2. (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia