Pharm

Pimavanserin

search

Pimavanserin, Nuplazid

  • See Also
  1. Parkinsonism
  2. Antipsychotic Medication
  3. Psychosis
  • Indications
  1. Parkinsonism-related Psychosis (Hallucinations, Delusions)
  • Dosing
  1. Start 34 mg orally daily
    1. Lower dose to 10 mg daily if on CYP3A4 Inhibitors
  • Mechanism
  1. Atypical Antipsychotic
  2. Serotonin 5HT2 Antagonist
  • Drug Interactions
  1. Metabolized by CYP3A4
  2. Avoid with strong CYP3A4 inducers
  • Adverse Effects
  1. See Antipsychotic Medication
  2. QTc Prolongation
  • Safety
  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation
  • Resources
  1. Pimavanserin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e6bea44-57d6-4bac-9328-46e1ee59f83b
  • References
  1. (2016) Med Lett Drugs Ther 58(1510): 160-5
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 42-3
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia