Pharm

Estazolam

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Estazolam, Prosom

  • See Also
  1. Benzodiazepine
  • Class
  1. Medium acting Benzodiazepine
  • Indication
  1. Insomnia
    1. Short-term use only (up to 12 weeks)
  • Dosing
  1. Adult: 1 to 2 mg orally at bedtime
  2. Elderly: 0.5 to 1 mg orally at bedtime
  • Safety
  1. Pregnancy Category X
  2. Avoid in Lactation
  3. Schedule IV Controlled Substance
  • Pharmacokinetics
  1. Onset: 20 minutes
  2. Duration: 6-8 hours
  3. Half-Life: 10-24 hours
  4. Metabolites are minimally active
  • Drug Interactions
  1. Strong CYP3A4 Inhibitors (e.g. Ketoconazole, Itraconazole)
    1. Avoid Estazolam with these agents
  • Adverse Effects
  1. See Benzodiazepine
  • Resources
  1. Estazolam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a1e3b4bf-22e9-430a-a768-4d86ae886c9e
  • References
  1. (2019) Med Lett Drugs Ther 61(1578): 121-6
  2. (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia