Neuro

Korsakoff's Disease

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Korsakoff's Disease, Korsakoff Psychosis, Alcohol Amnestic Disorder, Wernicke-Korsakoff Syndrome

  • See Also
  1. Wernicke's Encephalopathy (Acute Thiamine Deficiency)
  2. Beriberi (Chronic Thiamine deficiency)
  • Causes
  1. Untreated Acute Thiamine Deficiency (e.g. Alcoholism)
  2. See Acute Thiamine Deficiency for a full list of causes
  • Pathophysiology
  1. Follows Wernicke's Encephalopathy
  2. Lesions develop in mammillary bodies and Thalamus
  • Signs
  1. Life-long neurologic Impairment with learning difficulties
  2. Severe Short Term Memory loss
  3. Intact Immediate Memory
  4. Confabulation
  • Management
  1. Thiamine (See Wernicke's Encephalopathy)
  • Prognosis
  1. Life-long Impairment
  2. Improvement in 75% of patients with treatment
  • References
  1. Rendon et al. (2017) Crit Dec Emerg Med 31(6): 15-21