Depress

Atypical Depression

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Atypical Depression, Atypical Depressive Disorder

  • Epidemiology
  1. High risk for Suicide
  • Symptoms
  1. Hypersomnia
  2. Hyperphagia
    1. Carbohydrate craving
    2. Weight gain
  3. Interpersonal rejection sensitivity
  4. Heavy or leaden paralysis or arms and legs
  5. Mood reactivity
  • Diagnosis
  1. Over-eating with Hypersomnia is a sensitive marker
    1. Matza (2003) Arch Gen Psychiatry 60:817-26 [PubMed]
  • Management
  1. MAO Inhibitor
    1. Phenelzine (Nardil) 45-90 mg PO in divided doses
  2. Selective Serotonin Reuptake Inhibitors (SSRI)
    1. Not as affective for Atypical Depression