- Mu-Opioid receptor Agonist
-
Norepinephrine reuptake inhibitor
- Moderate to severe acute pain
- Severe renal Impairment
- Severe hepatic Impairment
-
Seizures
- Anaphylactoid Reaction
- Respiratory Depression
-
Schedule II Controlled Substance
- Immediate release
- Tapentadol 50-100 mg orally every 4-6 hours as needed (up to 600 mg/day)
- Decrease dose to 50 mg every 8 hours if moderate hepatic Impairment
- Extended release
- Tapentadol XR 50 mg orally twice daily (and titrate up to 250 mg twice daily)
- May start higher if transitioning from other Opioids
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